Nanoengineering for Mechanobiology

5th edition, 22-25 March 2020, Camogli (Genova), Italy

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About

Nanoengineering for Mechanobiology

The upcoming edition of the meeting is expected to host a stimulating multidisciplinary environment, with researchers belonging to different areas, from physics and engineering to biology and medicine, but sharing a common scientific interest. The main methodological focus will be posed on the application of advanced microscopy and spectroscopy approaches to follow the dynamics and measure the mechanical properties of single molecules and cells. Moreover, the scientific sessions will be flanked by a technological exhibit involving world-leading companies and high tech startups interested in presenting their solutions and services for the growing community of mechanobiology.

If you are curious about the history and spirit of N4M, have a look at the editorial of the special issue of Biophysical Reviews dedicated to the symposium: Science by the sea: how nanoengineering met mechanobiology in Camogli

N4M2020 at a glance

Overview

Structure of the meeting

The conference is organized over three days, starting with the opening session on Sunday afternoon, and closing the meeting after the Wednesday morning activity. The general structure is highlighted below.

  • Sunday 22/03
  • 17:00 - 19:00
  • Registration and welcome
  • Opening lectures
  • 19:00 - 22:00
  • Welcome dinner
  • Monday 23/03
  • 9:00 - 13:00
  • Scientific session 1
  • 15:00 - 19:00
  • Scientific session 2
  • 20:00 - 23:00
  • Night for Science: dinner and poster session
  • Tuesday 24/03
  • 9:30 - 13:00
  • Scientific session 3
  • 13:00 - 15:00
  • Lunch and poster session
  • 15:00 - 19:00
  • Scientific session 4
  • Wednesday 25/03
  • 9:00 - 13:00
  • Scientific session 5
  • 13:00 - 14:00
  • Farewell lunch

Keynote and Invited speakers

People bringing exciting science to N4M

David Beech
David Beech

Piezo1 force-sensing ion channels in cardiovascular health and disease

Vaishnavi Ananthanarayanan
Vaishnavi Ananthanarayanan

Single-molecule imaging of cytoplasmic dynein in vivo reveals the mechanism of motor activation and cargo capture

Yanlan Mao
Yanlan Mao

Coping with Stress: Tissue dynamics during growth and repair

Jaap den Toonder
Jaap den Toonder

Microfluidic technology as a tool for cell and tissue biomechanics

Ofer Feinerman
Ofer Feinerman

Communication by force in ants

Ulrich Schwarz
Ulrich Schwarz

Modelling the dynamics of non-muscle myosin II minifilaments

Guillaume Charras
Guillaume Charras

Dissecting the intercellular forces shaping tissues

Manuel Salmeron-Sanchez
Manuel Salmeron-Sanchez

Engineered 3D microenvironments for in vitro tissue models

David Sampson
David Sampson

Optical coherence elastography – optical coherence tomography at work in tissue biomechanics

Marino Arroyo
Marino Arroyo

Modeling the mechanics and self-organization of cells and tissues

Kristian Franze
Kristian Franze

Exploiting cellular mechanotransduction to minimize foreign body reactions to medical implants

Giancarlo Ruocco
Giancarlo Ruocco

Viscoelastic behaviour of protein aggregation in in neurodegenerative diseases

Lining Ju
Lining Ju

Novel single cell mechanobiology approach reveals an intermediate state of integrin αIIbβ3 that mediates platelet aggregation under disturbed flow

Kareem Elsayad
Kareem Elsayad

Variations on Spontaneous Brillouin Light Scattering Microscopy

Francesca Palombo
Francesca Palombo

Evaluating the micromechanics of tissue phantoms with Brillouin spectroscopy

Marco Lazzarino
Marco Lazzarino

Cardiomyocyte nanomechanics

Program

Detailed program of the meeting

Sunday 22/03
16:30 - 17:30 Registration
17:30 - 19:30 Opening Session
Aldo Ferrari, Silvia Caponi, Massimo Vassalli

N4M organizing committee

Welcome and Introduction

David Beech

University of Leeds, UK

Piezo1 force-sensing ion channels in cardiovascular health and disease

Vaishnavi Ananthanarayanan

EMBO Young Investigator
Indian Institute of Science, Bangalore, India

Single-molecule imaging of cytoplasmic dynein in vivo reveals the mechanism of motor activation and cargo capture

Yanlan Mao

EMBO Young Investigator
University College London, UK

Coping with Stress: Tissue dynamics during growth and repair

20:00 - 23:00 Welcome dinner
Monday 23/03
9:00 - 13:00 Molecular mechanobiology
Ulrich Schwarz

EBSA talk
University of Heidelberg, Germany

Modelling the dynamics of non-muscle myosin II minifilaments

Timothy Saunders

Mechanobiology Institute, National University of Singapore

Periodic Oscillations of Myosin-II Mechanically Proofread Cell-Cell Connections to Ensure Robust Formation of the Cardiac Vessel

Pasquale Bianco

University of Florence, Italy

Characterization of the functional diversity of the synthetic nanomachine powered by different muscle myosin isoforms

Impetux

Sponsor Talk
Impetux, Barcelona, Spain

SENSOCELL: a novel optical tweezers concept for cell and tissue mechanobiology

Lining Ju

University of Sydney, Australia

Novel single cell mechanobiology approach reveals an intermediate state of integrin αIIbβ3 that mediates platelet aggregation under disturbed flow

Arne Gennerich

Albert Einstein College of Medicine, New York, USA

Force generation of mammalian dynein-dynactin is augmented by Lis1

Marco Lazzarino

IOM-CNR, Trieste, Italy

Cardiomyocyte nanomechanics

Claudia Arbore

SIBPA Fellow
LENS, Florence, Italy

Multiple α-catenin molecules are required to resist tension on actin in adherens junctions

15:00 - 19:00 Mechanotransduction and mechanosensing
Kristian Franze

University of Cambridge, UK

Exploiting cellular mechanotransduction to minimize foreign body reactions to medical implants

Dan Cojoc

IOM-CNR, Trieste, Italy

Cell mechanics and mechanotransduction with optical tweezers

Marco Cantini

University of Glasgow, UK

Mechanotransduction on viscous substrates drives stem cell fate

Optics11

Sponsor Talk
Optics11, Amsterdam, The Netherlands

to be defined

Sylvain Gabriele

University of Mons, Belgium

Substrate area confinement is a key determinant of cell velocity in collective migration

Ines Lüchtefeld

ETH Zürich, Switzerland

Using Force-Controlled Micropipettes to Investigate the Influence of Cytoskeleton and Membrane Tension on the Single-Cell Mechanosensitive Response

Ana Garcia-Obregon

EBSA Student Award
University of Glasgow

Seeking the link between mechanical and metabolic activities in cell differentiation

Patrizia Romani

University of Padua, Italy

Crosstalk between extracellular matrix mechanical cues and metabolism

Francesco Morena

SIBPA Fellow
University of Perugia, Italy

Amazing Induction of Neuronal Commitment of Human Bone Marrow-Mesenchymal Stem Cells by Poly(butylene cyclohexanedicarboxylate) and its Ether-oxygen containing Random Copolyesters

20:00 - 23:00 Buffet dinner and Poster session
Tuesday 24/03
9:00 - 13:00 Comparative and correlative methods
David Sampson

University of Surrey, Guildford, UK

Optical coherence elastography – optical coherence tomography at work in tissue biomechanics

Kareem Elsayad

Vienna BioCenter, Vienna, Austria

Variations on Spontaneous Brillouin Light Scattering Microscopy

Claudia Testi

IIT, Rome, Italy

Brillouin microscopy for nuclear mechanical mapping

Jo Whetstone

Sponsor Talk
CoolLED, Andover, UK

LED illumination for transmitted light and fluorescence applications in microscopy

Giancarlo Ruocco

IIT, Rome, Italy

Viscoelastic behaviour of protein aggregation in in neurodegenerative diseases

Francesca Palombo

University of Exeter, UK

Evaluating the micromechanics of tissue phantoms with Brillouin spectroscopy

Oana Dobre

University of Glasgow

What Caging Force Cells Feel in 3D Hydrogels: A Mechanical Perspective

Martina Alunni Cardinali

University of Perugia, Italy

Mechanical and chemical characterization of human bone tissue by Brillouin and Raman micro-spectroscopy

13:00 - 15:00 Lunch and poster session
15:00 - 19:00 Mechanobiology of cell organization and applications
Manuel Salmeron-Sanchez

EBSA Talk
University of Glasgow, UK

Engineered 3D microenvironments for in vitro tissue models

Rudolf Leube

Aachen University, Germany

Emergent Features of the Epithelial Intermediate Filament Cytoskeleton

Xi Wu

ETH Zürich, Switzerland

Micro Topography Patterning of General Elastomer Surfaces for the Endothelialization of Ventricular Assist Devices

Nils Goedecke

Sponsor Talk
Heidelberg Instruments Nano, Zürich, Switzerland

NanoFrazor – A Nanofabrication Tool for 2D & 3D devices

Guillaume Charras

University College London, UK

Dissecting the intercellular forces shaping tissues

Jaap den Toonder

Eindhoven University of Technology, The Netherlands

Microfluidic technology as a tool for cell and tissue biomechanics

Marino Arroyo

Universitat Politècnica de Catalunya, Barcelona, Spain

Modeling the mechanics and self-organization of cells and tissues

Wednesday 25/03
9:00 - 13:00 Mechanobiology of cell organization and applications
Ofer Feinerman

Weizmann Institute of Science, Rehovot, Israel

Communication by force in ants

Alex Dommann

EMPA Dübendorf, Switzerland

How X-ray imaging techniques can support personalized health activities in the future

Luciana Bruno

Universitas de Buenos Aires, Argntina

Mechanics of rod-like mitochondria during microtubule-dependent transport

Eva Carvalho

EBSA Student Award
University of Porto, Portugal

Changing paradigms on de(myelination) processes – the fundamental role of mechanical properties

Janine Terra Erler

University of Copenhagen, Denmark

Extracellular matrix, mechanics and cancer progression

Carsten Schulte

University of Milan, Italy

Dissection of glycocalyx involvement in cellular nanotopograpy mechanosensing by advanced imaging and force spectroscopic measurements

Special Issue

European Biophysics Journal

For the 2020 edition of the symposium, we are partnering with Springer and with the European Biophysical Societies Association to provide access to a Special Issue of European Biophysics Journal (see below). The special issue will be edited by Silvia Caponi (lead editor), Aldo Ferrari and Massimo Vassalli.

European Biophysics Journal

The European Biophysics Journal publishes papers in the field of biophysics, defining biophysics as the study of biological phenomena using physical methods and concepts. The journal presents original papers, reviews and letters. The primary goal of this journal is to advance the understanding of biological structure and function by application of the principles of physical science, and by presenting the work in a biophysical context. Principal areas of interest include: structure and dynamics of biological macromolecules; membrane biophysics and ion channels; cell biophysics and organisation; macromolecular assemblies; biophysical methods and instrumentation; advanced microscopics; and system dynamics. The journal is published on behalf of the European Biophysical Societies' Association.

Registration

Participating to the meeting

The Nanoengineering for Mechanobiology symposium is organized in Camogli, a nice fishermen village near Genova, with the aim to bring together for three days junior and senior scientists passionate for the field of Mechanobiology. To enhance the interaction among the attendees, the core activities of the conference are organized inside the Hotel Cenobio dei Dogi which is also the accommodation for the participants.

Participation fees are set to 550€ for young students and early career researchers (accommodation in shared room) and 650€ for senior scientists (accommodation in single room).

Registration is open till March 1st, 2020 for poster only presentations.

To register, click on the button below. You will be redirected to the registration page, to select the subscription package and provide all the details of your contribution (service provided by DOUBLE EM SRL)

Register HERE

Bursaries

Support for students

Thanks to the support of external institutional sponsors and partners, we are able to grant a limited number of bursaries to encourage the participation of young students to the meeting. Please find additional details below

EBSA
EBSA Bursaries

The European Biophysical Societies Association is supporting 2 bursaries for the participation of EU PhD students and early career researchers (coming from countries other than Italy). Full details and rules can be found at the corresponding page of the EBSA website. EBSA will support up to 400€; to apply for the bursary, please download the official form, fill it with all the required details, and send it to the organizing committee at the address n4m@mechanobiology.eu.
EBSA bursaries have been assigned by the scientific committee.

SIBPA
SIBPA bursaries

The Italian Society of Pure and Applied Biophysics (SIBPA) is supporting the participation of younger members to the N4M meeting. In order to apply, you need to be a qualified member of the society or - if you qualify - apply to become a member before the submission deadline. Please download the call (Italian only) to get all the details and follow the procedure therein to apply.
SIBPA bursaries have been assigned by the scientific committee.

Organization

N4M 2020 is proudly organized by

Aldo Ferrari

Empa
Dübendorf, Switzerland

Aldo Ferrari
Silvia Caponi

IOM-CNR
Perugia, Italy

Silvia Caponi
Massimo Vassalli

James Watt School of Engineering
University of Glasgow, UK

Massimo Vassalli

Venue

Hotel Cenobio dei Dogi

Via Nicolò Cuneo, 34
16032 Camogli Genova, Italy
cenobio.it

How to get there

By train

The Camogli S.Fruttuoso station is 2 minutes walk from the Hotel and directly connected to the national railway network.

By car

Have a look at the directions provided by the Hotel or follow any navigation system. The Hotel Cenobio dei Dogi provides free parking for all attendees staying at the Hotel.

By plane

The nearest airport is Genova Cristoforo Colombo. From there, a frequent shuttle brings in 10min to the nearest train station, where a train to Camogli departs about every half an hour